Prediction: Sanders and Sellers are going to combine for 35-40 rushing attempts. The pair have been anywhere from 25-35 recently and I think the Gamecocks will view the Tiger run defense as the spot to attack. Sellers does a lot of scramble running, close to the same amount or more than designed runs the past five games and Missouri's defensive line should be able to handle the South Carolina offensive line, so expect some scrambles to escape pressure.
Key: Don't let either one break a big run and recover a fumble or two. Sellers doesn't have a ton of breakaway carries this year, but he does pull the ball down and get first downs on the ground a lot. Sanders on the other hand, has multiple 15+-yard runs in three games this year, including both of the Gamecocks' last two matchups. Those runs are where more than half his total yards came in those matchups. If the Tigers can keep them both from breaking big runs and just force them to keep the offense churning with short carries, eventually mistakes will be made. Sellers has nine fumbles this year, including two last week. Take advantage when one pops free.